I'm currently testing it on Vista Ultimate Ed. 32bit. Surprisingly, it's working quite well. I had a problem with earlier builds of Vista, but with the rtm, it seems ok. I did seem to get the old slow logon bug, even after updating my LS build to the final, though.

I imagine running it on 64bit Vista would have the same problems as running 64bit XP.

edit -

After downloading a file, if you pick "Open Folder" it doesn't open. (Note: You can still use explorer.exe as your file manager, and explorer the shell remains supressed.)

Can't seem to click through ghosted labels.

!shutdown seemed to crash LS.