It really depends on what you want LS to do. You can run LS on top of explorer if you want; however, it is best if you can kill the explorer.exe task.

Now...the installer process does change some system settings. Install it at home onto your hard drive and boot up. Configure LS to your needs and then set explorer back as the shell. Reboot and then move the LS folder to your pen drive. It isn't rocket science...hence why we have no walk through. Once at uni...kill explorer and start LS...reboot to reverse.