LiteStep runs fine on Vista except for these 2 issue's:
http://www.lsdev.org/bugs/view.php?id=28
http://www.lsdev.org/bugs/view.php?id=29
(should be fixed soon)

This if for the 32bit version of Vista. For the 64bit version (and the 64bit version of XP) there are additional problems.

There might be some module's with additional issue's, but I've never heard of them.