I have not run litestep since windows 98 and now I am running Vista Business on my newest laptop. I am just wondering if it is worth getting back into for Vista yet. I guess what I am really looking for are the opinions of people running LS with Vista.

I'm running LS on Vista. LS have some problems with systray icons disappearing, problems with the !shutdown bang command, but there´s a work around for the systray icons and you can use utilities like iShut for the !shutdown. It appears that hooked labels broke the transparency (at least that´s what is happening to me), I use a program called bLend to do the transparency and you can make all the windows transparent with this program too. In my case, if I activate the Aero theme the wallpaper disappear. Turning it off seems to fix this problem.
LS have some problems running on Vista, but it is usable.
Good luck!